What causes PAH?
A number of things can cause PAH. These include inherited genetic conditions, other diseases, and outside factors. There are also cases where the cause of PAH is not known.
|Idiopathic PAH (IPAH)1||Idiopathic means the cause is not known|
|Familial or heritable PAH (HPAH)1||This means the disease runs in a family|
|Connective tissue disorders (CTD)1||PAH associated with CTD|
|Congenital heart disease (CHD)1||PAH associated with CHD with repaired shunts|
|Other causes1||PAH associated with other diseases and conditions|
The 3 pathways that PAH treatments target2
Blood vessels in your lungs may be affected when there is either too much or too little of certain natural chemicals:
- Nitric oxide
There are PAH treatments available that target each of these pathways:
How UPTRAVI works
UPTRAVI targets the prostacyclin pathway. Your body may not make enough of the chemical prostacyclin. This can cause the blood vessels in your lungs to narrow.