UPTRAVI® (selexipag)—Titration Enables PAH Patients to Reach Their Highest Tolerated Doses1,2

UPTRAVI Titration Process

If a dose of UPTRAVI is missed, patients should take the missed dose as soon as possible unless the next dose is within the next 6 hours

If treatment is missed for 3 days or more, restart UPTRAVI at a lower dose and then retitrate

In GRIPHON, all patients completed their titration within the first 12 weeks.2

UPTRAVI doses achieved across the 3 prespecified groups in GRIPHON trial were as follows:

200-400 mcg BID: 23% of patients
600-1000 mcg BID: 31% of patients
1200-1600 mcg BID: 43% of patients

When patients were titrated to their highest tolerated dose, the benefit in delaying disease progression was consistent