*Actor Portrayal
UPTRAVI® IS THE ONLY ORAL PROSTACYCLIN PATHWAY THERAPY APPROVED TO:
DELAY DISEASE
PROGRESSION*
Real UPTRAVI® Patient
REDUCE THE RISK OF
PAH-RELATED
HOSPITALIZATION
Real UPTRAVI® Patient
&
UPTRAVI® can also improve the ability to exercise
(as measured by the 6-minute walk test)†
UPTRAVI® was studied in the largest trial of any FDA-approved PAH treatment.
STUDY OVERVIEW
- The trial included 1156 PAH patients — comparing 574 patients taking UPTRAVI® to
582 patients taking a placebo (sugar pill). - Nearly all patients fell within Functional Class II or III (PAH patients range from Functional Class I to IV).
- Patients on UPTRAVI® were treated for up to 4.2 years during this study. The median amount of time treated was 1.4 years.
- The mean age was 48 years; the majority of patients were white (65%) and female (80%).
SIDE EFFECTS
Side effects occurring more
frequently (by ≥3%)
for patients on UPTRAVI® compared to patients on placebo (sugar pill) are headache, diarrhea, jaw pain, nausea, muscle pain, vomiting, pain in arms or legs, temporary reddening of the skin (flushing), joint pain, low red blood cell count, less appetite than usual, and rash.
frequently (by ≥3%)
for patients on UPTRAVI® compared to patients on placebo (sugar pill) are headache, diarrhea, jaw pain, nausea, muscle pain, vomiting, pain in arms or legs, temporary reddening of the skin (flushing), joint pain, low red blood cell count, less appetite than usual, and rash.
*In a clinical trial of UPTRAVI®, PAH disease progression was defined as a serious event, such as hospitalization for PAH; the need to start injectable PAH medications or chronic oxygen therapy; atrial septostomy (a procedure where a hole is placed between two small chambers of the heart) or lung transplantation; a decline in 6-minute walk distance (6MWD) combined with worsening of functional class (FC) or need for additional PAH therapy; or death.
†Patients taking UPTRAVI® walked an average of 12 meters (about 39 feet) farther than patients taking placebo (sugar pill).
Real UPTRAVI® Patients
REAL PATIENTS,
REAL HOPE
Walk with real patients as they share their PAH stories in this heartfelt video series.
SUPPORT FOR EVERY STEP
OF
THE WAY
Once you and your doctor have decided that UPTRAVI® is right for you, you can join PAH Companion withMe* — a suite of patient support resources customized for your specific questions, needs, and interests.
The support and resources provided by PAH Companion withMe are not intended to provide medical advice, replace a treatment plan you receive from your doctor or nurse, or serve as a reason for you to start or stay on treatment.
*PAH Companion withMe requires a completed authorization form to enroll.
You may be able to delay PAH progression. Take the first step to start the conversation with your doctor
today.
today.
