UPTRAVI® (selexipag)

PAH keeps progressing
Keep exploring ways to help delay it.
Learn more about UPTRAVI®
What is UPTRAVI®?
UPTRAVI® is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.1
UPTRAVI® can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.1
It is not known if UPTRAVI® is safe and effective in children.1
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There are steps you can take that may delay PAH progression and it starts with talking to your doctor.
UPTRAVI® reduced the risk of PAH disease progression* by 40%.1
27% of patients treated with UPTRAVI® experienced a PAH disease progression event vs 41.6% of patients not taking UPTRAVI®.1
UPTRAVI® reduced the risk of PAH-related hospitalizations. This benefit was demonstrated in a clinical trial comparing patients taking UPTRAVI® to those not taking UPTRAVI®. Patients took UPTRAVI® for an average of 1.4 years.1
In this same clinical trial, patients taking UPTRAVI® walked an average of 12 meters (about 39 feet) farther than patients not taking UPTRAVI®, as measured by the 6-minute walk distance (6MWD).1
*In a clinical trial of UPTRAVI®, PAH disease progression was defined as a serious event, such as hospitalization for PAH; the need to start injectable PAH medications or chronic oxygen therapy; lung transplantation; a decline in 6-minute walk distance (6MWD) combined with worsening of functional class (FC) or need for additional PAH therapy; or death.
How the study was conducted:
UPTRAVI® was studied in the largest trial of any FDA-approved PAH treatment1
  • The trial included 1156 total PAH patients.
    • Compared 574 patients taking UPTRAVI® with 582 patients taking placebo (a sugar pill)
  • 80% of enrolled patients were treated with an endothelin receptor antagonist (ERA), phosphodiesterase type-5 inhibitor (PDE-5 inhibitor), or both for PAH
  • 20% of enrolled patients were not on any PAH treatment
  • Nearly all patients were FC II or FC III (PAH patients range from FC I to FC IV)
  • Patients taking UPTRAVI® were treated for an average of 1.4 years during this study
  • The trial included the most scleroderma-related PAH patients of any PAH trial (170 out of 1156)3,4
Play a role in the conversation. Ask your doctor ABOUT UPTRAVI®.
Even on a good day, your PAH could be progressing.5
UPTRAVI® can help delay disease progression when used alone or in combination with other PAH medications (an ERA, a PDE-5i or both).1
Learn how to discuss UPTRAVI® with your doctor and start exploring an additional angle to help delay disease progression by downloading this doctor discussion guide.
What is UPTRAVI®?
References: 1. UPTRAVI® (selexipag) full Prescribing Information. Actelion Pharmaceuticals US, Inc. 2. McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension. Circulation. 2009;119(16):2250-2294. 3. Gaine S, Chin K, Coghlan G, et al. Selexipag for the treatment of connective tissue disease-associated pulmonary arterial hypertension. Eur Respir J. 2017;50(2). 4. Aithala R, Alex A, Debashish D. Pulmonary hypertension in connective tissue diseases: an update. Int J Rheum Dis. 2017;20:5-24. 5. Lau EM, Humbert M, Celermajer DS. Early detection of pulmonary arterial hypertension. Nat Rev Cardiol. 2015;12(3):143-155.