Face PAH with
all you’ve got

 
Dosing for UPTRAVI® (selexipag) is not one-size-fits-all1
Each patient has a personal dose based on how his or her body responds and adjusts to the medicine. If you experience side effects that you cannot tolerate, your doctor may lower your dose in order to find what’s right for you.
Getting started with UPTRAVI®
Once you and your healthcare provider have decided that UPTRAVI® is right for you, Janssen CarePath will help you find the resources you may need to get started and stay on track.
Janssen CarePath can identify cost support options that may help with managing your out-of-pocket costs—whether you have commercial or private health insurance, government coverage such as Medicare or Medicaid, or have no insurance coverage.
Don’t miss the call from your specialty pharmacy.
Your healthcare provider orders UPTRAVI® from a specialty pharmacy. They will also determine if you need additional support services from a nurse to get started.
Before your prescription is filled, you’ll get a call from a specialty pharmacy to discuss coverage and shipping information. If you miss or accidentally decline the call, please call back as soon as possible so your medication is not delayed.
If your doctor has arranged any additional services, the specialty pharmacy will schedule those as well.
Once everything is all set, the pharmacy will ship the prescription directly to your door.
Discovering Your Dose
The Dose Adjustment Phase (also called titration) is how you and your doctor find your personal dose.
This is just a temporary part of treatment until you reach the dose that is right for you.
Download the Dose Adjustment Guide below for educational information regarding the Dose Adjustment Phase, including a section where you can record how you’re feeling and what’s inspiring you.
-How the Adjustment Phase works
Your doctor will start you at the lowest dose of UPTRAVI®: One 200 microgram (mcg) tablet, twice a day—once in the morning and once in the evening.
Starting with the lowest dose, your doctor will slowly increase your dose based on how you adjust to treatment until you reach your personal dose.
At some point during the Dose Adjustment Phase, you may experience side effects. If you experience side effects that you cannot tolerate, your doctor may lower your dose in order to find your personal dose.
UPTRAVI® dose strengths range from 200 mcg to 1600 mcg.
DO NOT CHANGE YOUR DOSE OR STOP taking UPTRAVI® unless your doctor tells you to.
+Which tablets will I take during dose adjustment?
Depending on which dose your doctor tells you to take, you may use a combination of tablets. With each dose adjustment during this phase, your doctor can easily add or remove a single tablet to increase or decrease your dose as needed.
For example:
If your dose is at 600 mcg twice a day, you’ll take three 200 mcg tablets in the morning and three 200 mcg tablets in the evening
If you reach a dose of 1000 mcg or higher, you may begin using 800 mcg tablets—along with 200 mcg tablets—until you reach your personal dose
The goal is not to get to the highest dose of UPTRAVI®, it’s to get to the dose that’s right for you
+What happens after the Dose Adjustment Phase?
After the Dose Adjustment Phase, you may have found your personal dose of UPTRAVI®. Your doctor may call this your maintenance dose. You’ll then take a single tablet of your personal (maintenance) dose twice a day, unless your doctor tells you otherwise.
+What should I do if I miss a dose?
If you miss a dose of UPTRAVI®, take it as soon as you remember. If your next scheduled dose is due within 6 hours, skip the missed dose. Take the next dose at your regular time.
If you miss 3 or more days of UPTRAVI®, call your doctor to see if your dose needs to be changed.
If you take too much UPTRAVI®, call your healthcare team or go to the nearest hospital emergency room right away.
+The Importance of Staying Involved in Your Therapy
Managing PAH can take some time and patience. Being open and honest with your healthcare team can be good for you.
Stick with the plan that you and your healthcare team decide is best for you
Remember to stay hopeful and focused on the big picture of how UPTRAVI® can help you
Tell your doctor about any side effects you have while taking UPTRAVI®
The goal is not to get to the highest dose of UPTRAVI®, it’s to get to the dose that’s right for you
Don’t be discouraged if you have to reduce your dose or stay on a lower one
In the clinical study, there were similar results when people reached the dose of UPTRAVI® that was right for them
+Who to Talk to for Support
Knowing what to expect beforehand can help you and your caregiver or loved ones be prepared for treatment
Ask your PAH healthcare team about ways to help manage some common side effects when you start UPTRAVI®
When you were prescribed UPTRAVI®, your doctor may have requested additional services to help you during the Dose Adjustment Phase (titration)
How to
take UPTRAVI®1
Take UPTRAVI® exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI® twice a day. Taking UPTRAVI® with food may help you tolerate UPTRAVI® better.
Swallow UPTRAVI® tablets whole. Do not split, crush, or chew tablets.
Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI®.
In a clinical trial of UPTRAVI®, the most common side effects included1
UPTRAVI®
n=575
Those not taking UPTRAVI® n=577 Those not taking UPTRAVI® n=577
Headache 65% 32%
Diarrhea 42% 18%
Jaw pain 26% 6%
Nausea 33% 18%
Muscle pain 16% 6%
Vomiting 18% 9%
Pain in arms
or legs
17% 8%
Temporary reddening of the skin (flushing) Temporary
reddening
of the skin
(flushing)
12% 5%
Joint pain 11% 8%
Low red blood cell count 8% 5%
Less appetite than usual 6% 3%
Rash 11% 8%
What you can do to help manage side effects:
Taking UPTRAVI® with food may help you tolerate the dose better if you’re having side effects with UPTRAVI®.
Tell your family and friends that you are starting UPTRAVI® and may need their assistance and support.
Always tell your doctor about any side effects, and do not change doses on your own. If you experience side effects that you cannot tolerate, your doctor may lower your dose in order to find your personal dose.
DO NOT CHANGE YOUR DOSE OR STOP taking UPTRAVI® unless your doctor tells you to.
If you’re a caregiver for someone with PAH, think of yourself as part of their support team
Caregivers can play several key roles
Educate
Learn about resources available to those with PAH. Click here for associations related to PAH.
Partner
Be a partner for the person you’re caring for throughout treatment, joining doctor’s appointments, asking questions, and taking notes.
Monitor
Keep track of your loved one’s progress and report to the doctor. Remain aware of dose adjustments and help your loved one track their side effects.
Advocate
Make your voice heard when working with the healthcare team to ensure all of your questions are answered and all of your loved one’s needs are met.
What caregivers can do about side effects
As a caregiver, you can help the person you’re caring for keep track of side effects. Be aware of and alert to the most common side effects. Keep track of their side effects at each dosage level. Speak up for them with their doctor about the impact of side effects. Encourage them to take UPTRAVI® with food to potentially tolerate their dose better.
Whether you are a patient or a caregiver, there’s more you can learn
There are resources to help you learn more about and get started on UPTRAVI®.
IMPORTANT SAFETY INFORMATION
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IMPORTANT SAFETY INFORMATION
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What is UPTRAVI®?
IMPORTANT SAFETY INFORMATION
References: 1. UPTRAVI® (selexipag) full Prescribing Information. Actelion Pharmaceuticals US, Inc.